Publications
2024
Malkawi A, Ohlund L*, Abdel Raham A, Sleno L, Siaj M. (2024) Co-stimulatory pathway competitive assay development using Liquid chromatogaphy tandem mass spectrometry (LC-MS/MS). Journal of Pharmaceutical and Biomedical Analysis. : JPBA-D-23-01573.
Mireault M*, Rose CF, Karvellas CJ, Sleno L. (2024). Perturbations in human bile acid profiles following drug-induced liver injury investigated by semi-targeted high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry. 9(38): e9731
Fernanda Vieira da Silva Cruz, Humberto Soares Caldeira Brant, Leanne Ohlund*, Lekha Sleno, Philippe Juneau. (2024). Tolerance and phytoremediation capacity of atrazine and S-metolachlor by two duckweeds. Environmental Science and Pollution Research. 31: (59382 – 59397)
Ghafari N*, Sleno, L. (2024) Recent advances in quantitative mass spectrometry-based metabolomics. Analytical Science Advances. 5(5-6): e2400007
Lépine M*, Robert MC, Sleno L. (2024) Discovery and Verification of Sjogren syndrom protein biomarkers in tears by targeted LC-MRM. Journal of Proteome Research. 23(6): 2219-2229
2023
Du J, Izquierdo D, Naoum J, Ohlund L*, Sleno L, Beisner BE, Lavaud J, Juneau P. (2023). Pesticideresponses of Arctic and temperate microalgae differ in relation to ecophysiological characteristics. Aquatic Toxicology. 254: 106323-30.
Tamnanloo F, Ochoa-Sanchez R, Oliveira MM, Lima C*, Lépine M*, Dubois K, Bosoi C, Tremblay M, Sleno L, Rose CF. (2023). Multiple ammonia-induced episodes of hepatic encephalopathy provoke neuronal cell loss in bile-duct ligated rats. JHEP Reports. 59(12): 100904.
Boulfekhar R, Ohlund L*, Kumaresan KM*, Megoura M, Warkentin TD, Ispas-Szabo P, Sleno L, Mateescu MA. (2023). Diamine Oxidase as a therapeutic enzyme: study of germination from vegetal sources and investigation of the presence of β-N-Oxalyl-L-α,β-diaminopropionic acid by LC-MS/MS. International Journal of Molecular Sciences. 24: 4625-4637
Lépine M*, Zambito O*, Sleno L. (2023). A targeted workflow investigating variations in the tear proteome by LC-MS/MS. ACS Omega. 8(34): 31168–31177.
Mireault M*, Prinville V, Ohlund L, Sleno L. (2023). Semi-targeted profiling of bile acids by high-resolution mass spectrometry in a rat model of drug induced liver injury. International Journal of Molecular Sciences. 24(3): 2489-2502
2022
Chabi K*, Sleno L. (2022). Estradiol, estrone and ethinyl-estradiol metabolism studied by high resolution LC-MS/MS using stable isotope labeling and trapping of reactive metabolites. Metabolites. 12(10): 931-947
Ousji O*, Sleno L. (2022). Structural Elucidation of Novel Stable and Reactive Metabolites of Green Tea Catechins and Alkyl Gallates by LC-MS/MS. Antioxidants. 11(9): 1635.
Golizeh M, Nam J, Chatelain E, Jackson Y, Ohlund LB*, Rasoolizadeh A, Vasquez Camargo F, Mahrouche L, Furtos A, Sleno L (co-corresponding author), Ndao M. (2022). New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice. Heliyon. 8(12): e12380
McKeown BT, Relja NJ, Hall SR, Gebremeskel S, MacLeod JM, Veinotte C, Bennett LG, Ohlund LB*, Sleno L, Jakeman DL, Berman JN, Johnston B, Goralski KB. (2022). Pilot Study of Jadomycin B Pharmacokinetics and Anti-Tumoral Effects in Zebrafish Larvae and Mouse Breast Cancer Xenograft Models. Can J Physiol Pharmacol. 100(11): 1065-1076
Frouni I, Kang W, Bédard D, Belliveau S, Kwan C, Hadj-Youssef S, Bourgeois-Cayer E, Ohlund L*, Sleno L, Hamadjida A, Huot P. (2022). Effect of glycine transporter 1 inhibition with bitopertin on parkinsonism and L-DOPA induced dyskinesia in the 6-OHDA-lesioned rat. European Journal of Pharmacology. 929: 175090.
Kochoni E, Aharchaou I, Ohlund L*, Rosabal M, Sleno L, Fortin C. (2022). New insights in copper homeostasis in the green alga Chlamydomonas reinhardhtii under low-Fe condition. Metallomics. 14(6):mfac033
2021
Geib T*, Iacob C, Jribi R, Fernandes J, Benderdour M, Sleno L. (2021). Identification of 4-Hydroxynonenal- Modified Proteins in Human Osteoarthritic Chondrocytes. Journal of Proteomics. 232: 104024.
Geib T*, Moghaddam G*, Supinski A*, Golizeh M*, Sleno L. (2021). Protein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS. Frontiers in Chemistry. 9: 736788
Sansoucy M*, Tremblay R, Carrington E, Marcotte I, Sleno L. (2021). Investigating byssogenesis with proteomic analysis of byssus, foot and mantle in Mytilus mussels by LC MS/MS. Proteomics. 21(2): 2000014.
Geib T*, Lento C, Marensi V, Thulasingam M, Haeggstrom J, Olsson M, Wilson D, Leslie E, Sleno L. (2021). Determining site occupancy of acetaminophen covalent binding to target proteins in vitro. Analytical Science Advances. 2(5-6): 263-271
Babych M, Nguyen PT, Côté-Cyr M, Kihal N, Quittot N, Golizeh M*, Sleno L, Bourgault S. (2021). Site-Specific Alkylation of Islet Amyloid Polypeptide Accelerates Self-Assembly and Potentiates Perturbation of Lipid Membranes. Biochemistry (ACS). 60(29): 2285-2299.
Ousji O*, Sleno L. (2021). In vitro metabolism of five bisphenol A analogs studied by LC-HRMS/MS. Journal of the American Society for Mass Spectrometry. 32(4): 847-859.
Takishita Y, Souleimanov A, Bourguet C, Ohlund LB*, Arnold AA, Sleno L, Smith DL. (2021). Pseudomonas sp. 23S produces a novel antagonistic compound against Clavibacter michiganensis subsp. Michiganensis a pathogen of tomato bacterial canker. Applied Microbiology. 1: 60-73.
2020
Geib T*, Thulasingam M, Haeggström J, Sleno L. (2020). Investigation of Clozapine and Olanzapine Reactive Metabolite Formation and Protein Binding by Liquid Chromatography-Tandem Mass Spectrometry. Chemical Research in Toxicology. 33(9): 2420-2431.
Ousji O*, Sleno L. (2020). Identification of in vitro metabolites of synthetic phenolic antioxidants BHT, BHA and TBHQ by LC-HRMS/MS. International Journal of Molecular Sciences. 21(24): 9525-9537.
Guesmi A*, Ohlund LB*, Sleno L. (2020). In vitro metabolism of sunscreen compounds by liquid chromatography-high resolution tandem mass spectrometry. Rapid Communications in Mass Spectrometry. 34(8): e8679.
Prinville V*, Ohlund LB*, Sleno L. (2020). Targeted Analysis of 46 Bile Acids to Study the Effect of Acetaminophen in Rat by LC-MS/MS. Metabolites. 10(1): E26.
Guesmi A*, Sleno L. (2020). In vitro metabolism of triclosan studied by liquid chromatography-high resolution tandem mass spectrometry. Anal Bioanal Chem. 412(2): 335-342.
Ousji O*, Ohlund L*, Sleno L. (2020). Comprehensive in vitro metabolism study of bisphenol A using liquid chromatography-high resolution tandem mass spectrometry. Chemical Research in Toxicology. 33(6): 1468-1477.
Lepine M*, Sleno L (co-corresponding author), Lesage J, Gagné S. (2020). A validated UPLC-MS/MS method for the determination of aliphatic and aromatic isocyanate exposure in human urine. Anal Bioanal Chem. 412(3): 753-762.
2019
Lépine M*, Sleno L, Lesage J, Gagné S. (2019). A validated LC/MS/MS method for 4,4′-methylenedianiline quantitation in human urine as a measure of 4,4′-methylene diphenyl diisocyanate exposure. Rapid Communications in Mass Spectrometry, 10.1002/rcm.838.
Lambert de Malezieu M, Courtel P, Sleno L, Abasq M-L, Ramassamy C. (2019). Synergistic properties of bioavailable phenolic compounds from olive oil: electron transfer and neuroprotective properties. Nutritional Neuroscience.
Geib T*, Lento C, Wilson DJ, Sleno L. (2019). Liquid Chromatography Tandem Mass Spectrometry Analysis of Acetaminophen Covalent Binding to Glutathione S-Transferases. Frontiers In Chemistry. 7: 558.
2018
Khairallah J, Ekbatan SS, Sabally K, Iskandar M, Hussain R, Nassar A, Sleno L, Rodes L, Prakash S, Donnelly D, Kubow S. (2018). Microbial Biotransformation of a Polyphenol-Rich Potato Extract Affects Antioxidant Capacity in a Simulated Gastrointestinal Model. Antioxidants. 7(3): 43-55.
Sadeghi Ekbatan S, Iskandar MM, Sleno L, Sabally K, Khairallah J, Prakash S, Kubow S. (2018). Absorption and Metabolism of Phenolics from Digests of Polyphenol-Rich Potato Extracts Using the Caco-2/HepG2 Co-Culture System. Foods. 7(1): pii: E8.
Geib T*, LeBlanc A*, Shiao TC, Roy R, Leslie EM, Karvellas CJ, Sleno L. (2018). Absolute quantitation of acetaminophen‐modified human serum albumin in acute liver failure patients by LC‐MS/MS. Rapid Communications in Mass Spectrometry. 32;(17):1573-82
Khairallah J, Sadeghi Ekbatan S, Sabally K, Iskandar MM, Hussain R, Nassar A, Sleno L, Rodes L, Prakash S, Donnelly DJ, Kubow S. (2018). Microbial biotransformation of a polyphenol-rich potato extract affects antioxidant capacity in a simulated gastrointestinal model. Antioxidants (Basel). 20;7(3). Sadeghi Ekbatan S, Iskandar MM, Sleno L, Sabally K, Khairallah J, Prakash S, Kubow S. (2018). Absorption and metabolism of phenolics from digests of polyphenol-rich potato extracts using the Caco-2/HepG2 co-culture system. Foods. 12;7(1).
2017
Kubow S, Iskandar MM, Melgar-Bermudez E, Sleno L, Sabally K, Azadi B, How E, Prakash S, Burgos G, Felde TZ. (2017) Effects of simulated human gastrointestinal digestion of two purple-fleshed potato cultivars on anthocyanin composition and cytotoxicity in colonic cancer and non-tumorigenic cells. Nutrients. 29;9(9).
Wang Y, Goralski KB, Roberts DJ, Landry K, Issa ME, Sleno L, Julien LC, Wood J, Hall RI. (2017). An observational study examining the effects of a surgically induced inflammatory response on the distribution of morphine and its metabolites into cerebrospinal fluid. Canadian Journal of Anesthesia. 64;(10):1009-1022.
2016
Zottig X, Laporte Wolwertz M, Golizeh M*, Ohlund L*, Sleno L, Bourgault S. Effects of oxidative post-translational modifications on structural stability and self-assembly of λ6 immunoglobulin light chain. (2016). Biophysical Chemistry. 219:59-68.
Chalifour A, LeBlanc A*, Sleno L, Juneau P. (2016). Sensitivity of Scenedesmus obliquus and Microcystis aeruginosa to atrazine: effects of acclimation and mixed cultures, and their removal ability. Ecotoxicology. 25;(10):1822-31
Ekbatan SS, Sleno L, Sabally K, Khairallah J, Azadi B, Rodes L, Prakash S, Donnelly DJ, Kubow S. (2016). Biotransformation of polyphenols in a dynamic multistage gastrointestinal model. Food Chemistry. 204: 453-62.
Waller DD, Jansen G, Golizeh M*, Dejgaard K, Mancuso J, Tsantrizos YS, Roy R, Sebag M, Sleno L, Thomas DY. (2016). A covalent cysteine-targeting kinase inhibitor of Ire1 permits allosteric control of endoribonuclease activity. ChemBioChem. 17(9): 843-51.
Sabally K, Sleno L, Jauffrit JA, Iskandar M, Kubow S. (2016). Inhibitory effects of apple peel polyphenol extract on the formation of heterocyclic amines in pan fried beef patties. Meat Science. 117: 57-62.
Geib T*, Sleno L, Hall RA, Stokes CS, Volmer D. (2016). Triple quadrupole versus high-resolution quadrupole-time-of-flight mass spectrometry for quantitative LC-MS/MS analysis of 25-hydroxyvitamin D in human serum. Journal of the American Society of Mass Spectrometry. 27(8): 1404-10.
Golizeh M*, Geib T*, Sleno L. (2016). Identification of 4-hydroxynonenal protein targets in rat, mouse and human liver microsomes by 2D-LC-MS/MS. Rapid Communications in Mass Spectrometry. 30(13): 1488-94.
2015
Wagner M*, Ohlund LB*, Shiao TC, Vézina A, Annabi B, Roy R, Sleno L. (2015). Isotope-labeled differential profiling of metabolites using N-benzoyloxysuccinimide derivatization coupled to liquid chromatography/high-resolution tandem mass spectrometry. Rapid Communications in Mass Spectrometry. 29: 1632-40.
Golizeh M*, Schneider C*, Ohlund LB*, Sleno L. (2015). Dataset from proteomic analysis of rat, mouse, and human liver microsomes and S9 fractions. Data in Brief. 3: 95-98.
Golizeh M*, Schneider C*, Ohlund LB*, Sleno L. (2015). Multidimensional LC–MS/MS analysis of liver proteins in rat, mouse and human microsomal and S9 fractions. EuPA Open Proteomics. 6: 16-27.
Percy AJ, Tamura-Wells J, Albar JP, Aloria K, Amirkhani A, Araujo GDT, Arizmendi JM, Blanco FJ, Canals F, Cho JY, Colome-Calls N, Corrales FJ, Domont G, Espadas G, Fernandez-Puente P, Gil C, Haynes PA, Hernaez ML, Kim JY, Kopylov A, Marcilla M, McKay MJ, Mirzaei M, Molloy MP, Ohlund LB*, Paik YK, Paradela A, Raftery M, Sabido E, Sleno L, Wilffert D, Wolters, JC, Yoo JS, Zgoda V, Parker CE, Borchers CH. (2015). Inter-laboratory evaluation of instrument platforms and experimental workflows for quantitative accuracy and reproducibility assessment. EuPA Open Proteomics. 8: 6-15.
Rafiei A*, Sleno L. (2015). Comparison of peak picking workflows for untargeted LC-HRMS metabolomics data analysis. Rapid Communications in Mass Spectrometry. 29: 119-127. Golizeh M*, LeBlanc A*, Sleno L. (2015). Identification of acetaminophen adducts of rat liver microsomal proteins using 2D-LC-MS/MS. Chemical Research in Toxicology. 28(11): 2142-50.
2014
Wilson JA, Goralski KB, Soroka SD, Morrison M, Mossop P, Sleno L, Wang Y, Anderson DR. (2014). An evaluation of oral dabigatran etexilate pharmacokinetics and pharmacodynamics in hemodialysis. Journal of Clinical Pharmacology. 54(8): 901-9.
Golizeh M*, Abusarah J, Benderdour M, Sleno L. (2014). Covalent binding of 4-hydroxynonenal to matrix metalloproteinase 13 studied by liquid chromatography-mass spectrometry. Chemical Research in Toxicology. 27(9): 1556-65.
LeBlanc A*, Shiao TC, Roy R, Sleno L. (2014). Absolute quantitation of NAPQI-modified rat serum albumin by LC-MS/MS: monitoring acetaminophen covalent binding in vivo. Chemical Research in Toxicology. 27(9): 1632-39.
Sleno L Ed. (2014, e-book) Applications of High-Resolution Mass Spectrometry in Drug Discovery and Development (Future Science, London) 1: 174.
2013
Golizeh M*, Sleno L. (2013). Optimized proteomic analysis of rat liver microsomes using dual enzyme digestion with 2D-LC-MS/MS. Journal of Proteomics. 82: 166-178.
Chu FL*, Sleno L, Yaylayan VA. (2013). Diagnostic ions for the analysis of phenylalanine adducts of acrylamide and styrene by ESI-QTOF mass spectrometry. Journal of Agricultural and Food Chemistry. 61(43): 10246-52.
Arnold AA, Byette F, Séguin-Heine MO, Leblanc A*, Sleno L, Tremblay R, Pellerin C, Marcotte I. (2013). Solid-state NMR structure determination of whole anchoring threads from the blue mussel Mytilus edulis. Biomacromolecules. 14(1): 132-41.
2012
Chan JN, Vuckovic D, Sleno L, Olsen JB, Pogoutse O, Havugimana P, Hewel JA, Bajaj N, Wang Y, Musteata MF, Nislow C, Emili A. (2012). Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization. Molecular and Cellular Proteomics. 11(7): M111.016642.
Sleno L. (2012). The use of mass defect in modern mass spectrometry. (Special Feature: Tutorial) Journal of Mass Spectrometry. 47(2): 226-36.
LeBlanc A*, Arnold A, Genard B, Nadalini JB, Séguin Heine MO, Marcotte I, Tremblay R, Sleno L. (2012). Determination of isotopic labeling of proteins by precursor ion scanning liquid chromatography tandem mass spectrometry of derivatized amino acids applied to nuclear magnetic resonance studies. Rapid Communications in Mass Spectrometry. 26: 1165-74.
Pirastru L, Perreault F, Chu FL*, Oukarroum A, Sleno L, Popovic R, Dewez D. (2012). Long-term stress induced by nitrate deficiency, sodium chloride, and high light on photosystem II activity and carotenogenesis of green alga Scenedesmus sp. Botany. 90(10): 1007-14.
Iglesias J, Sleno L, Volmer D. (2012). Isotopic labeling of metabolites in drug discovery applications. (Review) Current Drug Metabolism. 13(9): 1213-25.
2011
Pirastru L, Darwish M, Chu FL*, Perreault F, Sirois L, Sleno L, Popovic R. (2011). Carotenoid production and change of photosynthetic functions in Scenedesmus sp. exposed to nitrogen-limitation and acetate treatment. Journal of Applied Phycology. 24(1): 117-24.
Chu FL*, Sleno L, Yaylayan VA. (2011). Isotope labeling studies on the formation of multiple addition products of alanine in the pyrolysis residue of glucose/alanine mixtures by high esolution ESI-TOFMS. Journal of Agricultural and Food Chemistry. 59(21): 11629-34.
Chu FL*, Pirastru L, Popovic R, Sleno L. (2011). Carotenogenesis up-regulation in Scenedesmus sp. using a targeted metabolomics approach by LC-HRMS. Journal of Agricultural and Food Chemistry. 59(7): 3004-13.
LeBlanc A*, Sleno L. (2011). Atrazine metabolism in human microsomes: Detection of novel metabolites and glutathione adducts by LC-MS. Chemical Research in Toxicology. 24(3): 329-39.
2010
Mitrea N, LeBlanc A*, St-Onge M, Sleno L. (2010). Assessing covalent binding of reactive drug metabolites by complete protein digestion and LC-MS analysis. Bioanalysis. Jul;2(7):1211-21
Leblanc A*, Shiao TC, Roy R, Sleno L. (2010) Improved detection of reactive metabolites with a bromine-containing glutathione analog using mass defect and isotope pattern matching. Rapid Communications in Mass Spectrometry. May 15;24(9):1241-50