Conférences

Oriana Zambito*, Nejia Lassoued, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Proteomic and Metabolomic Analysis of Colon and Feces from Proximal and Distal Regions in Healthy Mice. Oral

Nathan Ghafari*, Iskren Menkovic, Pamela Lavoie, Michel Boutin, Christiane Auray-Blais, Lekha Sleno. Targeted and untargeted metabolomics of Hunter syndrom model in mouse liver by LC-MS/MS. Oral

Oriana Zambito*, Nejia Lassoued, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Quantitative proteomics and metabolomics of Hirschsprung disease in two mouse models. Poster

Maggy Lépine*, Oriana Zambito*, Marie-Claude Robert, Lekha Sleno. Targeted LC-MS/MS workflow for measuring quantitative changes in the tear proteome. Poster

Sleno L. Les défis du traitement de données en métabolomique et protéomique par spectrométrie de masse.

Oriana Zambito*, Neija Lassoued, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Metabolite and protein perturbations In the Tash T mouse model of Hirschsprung’s disease. Poster

Lekha Sleno, Myriam Mireault*, Christopher F Rose, Constantine J Karvellas. Perturbations in human bile acid profiles following drug induced liver injury investigated using semi-targeted high-resolution mass spectrometry.  Poster

Carima Lima*, Leanne Ohlund, Lekha Sleno. Method comparison for untargeted analysis of plasma proteome by LC-HRMS/MS. Poster

Kahina Chabi*, Lekha Sleno. Studying kinetic isotope effects in the formation of reactive metabolites using in vitro metabolism incubations and LC-HRMS/MS. Poster

Maggy Lépine*, Marie-Claude Robert, Lekha Sleno. Targeted LC-MS/MS workflow for measuring quantitative changes in the tear proteome. Poster

Oriana Zambito*, Neija Lassoued, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Quantitative proteomics and metabolomics of Hirschsprung disease in two mouse models. Poster

Nathan Ghafari*, Jeffrey Li, Stan Kubow, Kessen Patten, Lekha Sleno. Combining LC-MS based metabolomics and proteomics to study biological perturbation. Poster

Carina Lima*, Leanne Ohlund, Kevin Ly, Maxim Isabelle, Victoria Miller, Hugo Gagnon, Lekha Sleno. A comparison of sample preparation, data acquisition and data processing workflows for untargeted bottom-up plasma proteomics. Poster

Nathan Ghafari*, Lekha Sleno. Untargeted metabolomics workflows using correlation analysis to uncover links between metabolic pathways. Poster

Said Matar*, Lekha Sleno. Assessment of exposure to oxybenzone, synthetic antioxidants and triclosan using targeted and untargeted LC-MS/MS of urine samples. Poster

Kathrina Mae Kumaresan*, Nathan Ghafari*, Lekha Sleno. Increasing the detectability of phosphorylated metabolites by LC-HRMS/MS. Poster

Sleno L, Lepine M*, Zambito O*, Robert M-C. (2024). Targeted LC-MS/MS workflow for measuring quantitative changes in the tear proteome.

Oriana Zambito*, Neija Lassoued, Rodolphe Soret, Nicolas Pilon, Lekha Sleno, Analyse multi-omique de la maladie de Hirschsprung dans trois modèles de souris. Poster

Maggy Lépine*, Marie-Claude Robert, Lekha Sleno. Tear proteomics study of patients with mucous membrane pemphigoid for biomarker discovery. Poster

Nathan Ghafari*, Sherin Nawaito, Ouliana Souchkova, Nicolas Pilon, Lekha Sleno, Étude métabolomique ciblée et non ciblée du syndrome des ovaires polykystiques (PCOS) dans un modèle de souris par LC-MS/MS. Poster

Kahina Chabi*, Lekha Sleno, LC-MS/MS screening for reactive metabolites using trapping agents and isotopic labeling. Poster

Lekha Sleno, Nathan Ghafari*, Maggy Lépine*, Carina Lima*, Leanne Ohlund. Quantitative proteomics for biomarker discovery in mouse models of disease. Oral

Lekha Sleno. Untargeted metabolomics workflows using correlation analysis uncover links between metabolic pathways. Oral

Carina Lima*, Maggy Lépine*, Dylan Ngoya*. Souleiman Jmii, Isaac Ruiz, Mélanie Tremblay, Francis Noel, Paul Jaouen, Line Cantin, Christopher Rose, Marie-Claude Robert, Laurent Cappadocia, Elodie Boisellier, Lekha Sleno, Développement d’une méthode LC-MRM ciblée de protéines S100 et annexines et son application pour l’analyse de larmes humaines. Poster

Oriana Zambito*, Neija Lassoued, Rodolphe Soret, Nicolas Pilon, Lekha Sleno, Multi-omic analysis of Hirschsprung disease in three mouse models by LC-MS/MS. Poster

Kathrina Mae Kumaresan*, Nathan Ghafari*, Yann Chabi, Claire Bénard, Christiane Auray-Blais, Lekha Sleno​, Increasing the detectability of phosphorylated metabolites as disease biomarkers by LC-HRMS/MS. Poster

Nathan Ghafari*, Maggy Lépine*, Iskren Menkovic, Pamela Lavoie, Michel Boutin, Christiane Auray-Blais, Lekha Sleno, Étude multi-omique du syndrome de Hunter (MPS II) par spectrométrie de masse à haute résolution.  Poster

Said Matar*, Leanne Ohlund, Lekha Sleno, L’optimisation d’une méthode pour la caractérisation de métabolites sulfatés et la déconjugaison de métabolites phase II, étudié par LC-HRMS/MS. Poster

Maggy Lépine*, Marie-Claude Robert, Lekha Sleno, Development of targeted quantitative methods for the analysis of human tears by liquid chromatography coupled with tandem mass spectrometry. Oral

Kathrina Mae Kumaresan^*, Nathan Ghafari*, Yann Chabi, Claire Bénard, Christiane Auray-Blais, Lekha Sleno, Increasing the detectability of phosphorylated metabolites by LC-HRMS/MS. Oral

Said Matar*, Leanne Ohlund, Lekha Sleno, optimized in vitro formation of sulfated metabolites and deconjugation of phase II metabolite studied by LC-HRMS/MS. Oral

Oriana Zambito*, Nejia Lassoued, Rodolphe Soret, Nicolas Pilon, Lekha Sleno, Multi-omic analysis of Hirschsprung’s disease in three mouse models. Oral

Nathan Ghafari*, Sherin Nawaito, Ouliana Souchkova, Nicolas Pilon, Lekha Sleno, Metabolomics study of polycystic ovary syndrome (PCOS) in a mouse model by LC-MS. Oral

Kahina Chabi*, Lekha Sleno, Screening of Reactive Metabolites by LC-MS/MS Using Different Trapping Agents and Isotopic Labeling. Poster

Lekha Sleno, Nathan Ghafari*, Maggy Lépine*, Carina Lima*, Leanne Ohlund, Multi-omics for biomarker discovery in disease models. Oral

Nathan Ghafari*, Cassandra Athanase*, Maidenn Lacroix*, Lekha Sleno, Correlation analysis to improve metabolome coverage for studying disease models. Poster

Maggy Lépine*, Marie-Claude Robert, Lekha Sleno. Targeted workflow to investigate the tear proteome of patient with Sjogren’s syndrome by LC-MS/MS. Poster (prix de présentation).

Nathan Ghafari*, Lekha Sleno. Testing different workflows for targeted and untargeted metabolomics. Oral.

Oriana Zambito*, Leanne Ohlund, Chirine Toufaily, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Multi-omic analysis of Hirschsprung’s disease in a mouse model. Poster.

Kathrina Mae Kumaresan^*, Leanne Ohlund, Rym Boulfekhar, Meriem Megoura, Thomas D. Warkentin, Pompilia Ispas-Szabo, Mircea Alexandru Mateescu, Lekha Sleno. Detection and quantification of the neurotoxin β-ODAP in pea seedling extracts. Poster.

Carina Lima*, Maggy Lépine, Souleimen Jmii, Laurent Cappadocia, Lekha Sleno. A comparative analysis of sample preparation methods for LC-MS/MS proteomics. Poster.

Nathan Ghafari*, Lekha Sleno. Untargeted and targeted metabolomics by LC-MS/MS for studying metabolic perturbations in biological samples. Poster.

Myriam Mireault*, Constantine J Karvellas, Christopher F Rose, and Lekha Sleno. Semi-targeted LC-HRMS/MS analysis of bile acids to decipher the effects of drug-induced liver injury in humans. Poster.

Lekha Sleno. Reactive metabolites of xenobiotics and their covalent binding to proteins studied by LC-MS/MS. Invited talk.

Maggy Lépine*, Marie-Claude Robert, Lekha Sleno. Targeted workflow to investigate the tear proteome of patient with Sjogren’s syndrome by LC-MS/MS. Poster.

Oriana Zambito*, Leanne Ohlund, Nejia Lassoued, Rodolphe Soret, Nicolas Pilon,

Lekha Sleno. Untargeted proteomic analysis of proximal and distal locations of colon and fecal samples by LC-MS/MS. Poster.

Carina Lima*, Maggy Lépine*, Souleimen Jmii, Laurent Cappadocia, Lekha Sleno.A comparative analysis of sample preparation methods for LC-MS/MS proteomics. Poster.

Lekha Sleno, Maggy Lépine*, Marie-Claude Robert. Studying disruptions in the tear proteome by innovative LC-MS/MS targeted workflows. Invited talk.

Nathan Ghafari*, Iskren Menkovic, Pamela Lavoie, Michel Boutin, Christiane Auray-Blais, Lekha Sleno. Targeted and untargeted metabolomics of mucopolysaccharidoses model in mouse liver by LC-MS/MS.

Maggy Lépine*, Marie-Claude Robert, Lekha Sleno. Targeted workflow for investigating tear proteome of patient with Sjogren’s syndrome by LC-MS/MS. Poster.

Oriana Zambito*, Leanne Ohlund, Lassoued N, Soret R, Pilon N, Lekha Sleno. Untargeted proteomic and metabolomic analysis of proximal and distal colon and fecal samples by LC-MS/MS. Poster.

Myriam Mireault*, Lekha Sleno. Untargeted metabolomics of human urine from the hPOP consortium: profiling variations by gender,age, body mass index, ethnicity and nutrition. Poster.

Carina Lima*, Maggy Lépine*, Lekha Sleno. A comparative analysis of different sample preparation methods for human plasma proteomics by LC-MS/MS. Poster.

Lekha Sleno, Said Matar*, Ons Ousji*. Structural elucidation of BPB, BPAP and TBBPA metabolites by LC-HRMS/MS. Poster.

Nathan Ghafari*, Iskren Menkovic, Pamela Lavoie, Michel Boutin, Christiane Auray-Blais, Lekha Sleno. Hunter syndrome model in mouse studied by untargeted and targeted metabolomics. Poster.

Oriana Zambito*, Nejia Lassoued, Rodolphe Soret, Nicolas Pilon, Lekha Sleno^. Investigating differences between proximal and distal colon and fecal samples in healthy mouse model using untargeted multi-omic analysis. Poster.

Myriam Mireault*, Lekha Sleno. Metabolic variations in urine profiling in a populational study from the hPOP consortium using untargeted LC-MS/MS analyses. Poster.

Lekha Sleno, Benhadji Serrad I*, Ousji O*, Matar S*, Ghafari N*, Ohlund L. Building LC-MS/MS spectral libraries to detect metabolites of environmental contaminants in urine. Poster.

Lekha Sleno. LC-MS/MS methodologies for biomarker discovery and exposomics research. Invited talk.

Nathan Ghafari*, Iskren Menkovic, Pamela Lavoie, Michel Boutin, Christiane Auray-Blais, Lekha Sleno. Targeted and untargeted metabolomics of Hunter syndrome model in mouse liver by LC-MS/MS. Oral.

Kathrina Mae Kumaresan*, Lekha Sleno. Increasing the detectability of phosphorylated metabolites by LC-HRMS/MS. Oral.

Oriana Zambito^*, Nejia Lassoued, Rodolphe Soret, Nicolas Pilon, Lekha Sleno^. Untargeted metabolomic and proteomic analysis of colon and fecal samples by LC-MS/MS. Oral.

Maggy Lépine*, Marie-Claude Robert, Lekha Sleno. A targeted LC-MS/MS workflow for investigating the tear proteome of Sjogren’s syndrome patients. Oral (presentation prize).

Myriam Mireault*, Lekha Sleno. Metabolic variations in human urine and plasma profiles from the hPOP consortium using untargeted LC-MS/MS analyses. Oral.

Lekha Sleno. LC-MS/MS methodologies for biomarker discovery and exposomics research. Invited talk.

Oriana Zambito*, Nejia Lassoued, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Studying the metabolome and the proteome of colon and fecal samples by LC-MS/MS. Poster

Maggy Lépine*, Marie Claude Robert, Lekha Sleno. Potential diagnostic biomarkers of Sjogren’s syndrome from targeted tear proteomics. Poster

Lekha Sleno, Nathan Ghafari*, Oriana Zambito*. Combining targeted and untargeted workflows and correlation analysis for metabolomics studies. Oral

Sleno L, Lépine M, Robert M-C. Studying disruptions in the tear proteome by targeted LC-MS/MS. Oral

Sleno Lekha . Analyzing drug adducts by mass spectrometry. Oral

Ons Ousji*, Lekha Sleno. Étude de métabolisme des contaminants environnementaux par LC-HRMS/MS, Oral (invited).

Lekha Sleno. Metabolism studies of environmental contaminants and elucidating protein binding targets of acetaminophen by LC-MS/MS. Invited talk.

Ons Ousji*, Mbarka Bchetnia, Catherine Laprise, Lekha Sleno. Proteomic and metabolomic analysis of an orphan disease: epidermolysis bullosa simplex (EBS). Poster.

Maggy Lépine*, Oriana Zambito, Jean-Yves Sahyoun, Marie-Claude Robert, Lekha Sleno. Discovering protein biomarkers for ocular mucous membrane pemphigoid in human tears. Poster (prix de presentation).

Oriana Zambito*, Leanne Ohlund, Chirine Toufaily, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Multi-omic analysis of Hirschsprung’s disease.Poster.

Maggy Lépine*, Oriana Zambito*, Jean-Yves Sahyoun, Marie-Claude Robert, Lekha Sleno. Discovering protein biomarkers for ocular mucous membrane pemphigoid in human tears. Oral and Poster.

Oriana Zambito*, Leanne Ohlund, Chirine Toufaily, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Multi-omic analysis of Hirschsprung’s disease in a mouse model.Oral & Poster.

Ons Ousji*, Mbarka Bchetnia, Catherine Laprise, Lekha Sleno. Analyse métabolomique et protéomique de l’épidermolyse bulleuse simple (EBS). Poster.

Maggy Lépine*, Oriana Zambito*, Jean-Yves Sahyoun, Marie-Claude Robert, Lekha Sleno. Étude protéomique de larmes de patients atteints du pemphigoïde muqueux. Poster.

Myriam Mireault*, Lekha Sleno. Optimisation de méthodes de préparation d’échantillons et d’analyse LC-MS du plasma humain pour des études métabolomiques. Poster.

Nathan Ghafari*, Lekha Sleno. Analyse métabolomique ciblée de matrices biologiques par LC-MS/MS. Poster.

Oriana Zambito*, Leanne Ohlund, Chirine Toufaily, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Analyse multi-omique de la maladie de Hirschsprung dans un modèle de souris.Poster.

Ons Ousji*, Mbarka Bchetnia, Catherine Laprise, Lekha Sleno. Untargeted LC-MS/MS metabolomics analysis of Epidermolysis bullosa simplex (EBS) in keratinocytes. Poster.

Maggy Lépine*, Oriana Zambito*, Jean-Yves Sahyoun, Marie-Claude Robert, Lekha Sleno. Targeted workflow to investigate the tear proteome of mucous membrane pemphigoid patients by LC-MS/MS. Poster.

Myriam Mireault*, Lekha Sleno. Comparison of sample preparation and MS/MS acquisition methods to identify polar metabolites in human plasma. Poster.

Oriana Zambito*, Leanne Ohlund, Chirine Toufaily, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Untargeted metabolomic analysis of Hirschsprung’s disease in a mouse model.Poster.

Kahina Chabi*, Lekha Sleno. Reactive metabolites of tienilic acid studied by LC-MS/MS using different trapping agents. Poster.

Lekha Sleno, Ikram Benhadji Serradj*, Ons Ousji*. Untargeted and targeted analysis of chemical exposures in urine by liquid chromatography-multiple reaction monitoring and high-resolution tandem mass spectrometry. Poster.

Lekha Sleno, Ons Ousji*, Ikram Benhadji Serradj*. Bioanalytical workflows for assessing our exposure to environmental contaminants. Invited talk.

Lekha Sleno, Ons Ousji*, Ikram Benhadji Serradj*. Bioanalytical workflows for assessing our exposure to environmental contaminants. Invited talk.

Ons Ousji*, Said Matar*, Lekha Sleno. Metabolism studies of environmental contaminants for identifying biomarkers of exposure by LC-HRMS/MS. Oral (prix de présentation).

Maggy Lépine*, Oriana Zambito*, Jean-Yves Sahyoun, Marie-Claude Robert, Lekha Sleno. Discovering protein biomarkers for ocular mucous membrane pemphigoid in human tears. Oral.

Myriam Mireault*, Lekha Sleno. Effect of acetaminophen-induced acute liver failure on bile acid profiles in human serum using semi-targeted LC-HRMS/MS analysis. Oral.

Nathan Ghafari*, Lekha Sleno. Metabolome coverage from targeted and untargeted LC-MS/MS methods. Oral.

Oriana Zambito*, Leanne Ohlund, Chirine Toufaily, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Multi-omic analysis of Hirschsprung’s disease in a mouse model. Oral.

Lekha Sleno. Adventures in developing mass spectrometry tools to study protein covalent binding of reactive metabolites. Invited lecture.

Oriana Zambito*, Leanne Ohlund, Chirine Toufaily, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Analyse multi-omique de la maladie de Hirschsprung dans un modèle de souris. Oral (selected abstract).

Maggy Lépine*, Oriana Zambito*, Jean-Yves Sahyoun, Marie-Claude Robert, Lekha Sleno. Étude protéomique de larmes de patients atteints du pemphigoïde muqueux. Poster.

Maggy Lépine*, Oriana Zambito*, Jean-Yves Sahyoun, Marie-Claude Robert, Lekha Sleno. Discovering protein biomarkers for ocular mucous membrane pemphigoid in human tears. Oral.

Myriam Mireault*, Constantine J Karvellas, Christopher F Rose, Lekha Sleno. Semi-targeted LC-HRMS/MS analysis to decipher the effects of acetaminophen on human bile acid profiles. Oral.

Nathan Ghafari*, Lekha Sleno. Metabolome coverage from targeted and untargeted LC-MS/MS methods. Oral (prix de présentation).

Oriana Zambito*, Leanne Ohlund, Chirine Toufaily, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Multiomic analysis of Hirschsprung’s disease in a mouse model.  Oral.

Said Matar*, Ons Ousji*, Lekha Sleno.In vitro metabolism of BPA analogs by LC-HRMS/MS. Poster.

Ons Ousji*, Mbarka Bchetnia,William Bourumeau, Catherine Laprise, Lekha Sleno. Integration of transcriptomic, proteomic and metabolomic data to decipher molecular perturbations in epidermolysis bullosa simplex. Poster.

Nathan Ghafari*, Lekha Sleno. Metabolome coverage from targeted and untargeted LC-MS/MS methods. Poster.

Maggy Lépine*, Oriana Zambito*, Jean-Yves Sahyoun, Marie-Claude Robert, Lekha Sleno. Étude protéomique de larmes de patients atteints du pemphigoïde muqueux. Poster.

Myriam Mireault*, Constantine J Karvellas, Christopher F Rose, Lekha Sleno. Effects of acetaminophen on human bile acids using a semi-targeted LC-HRMS/MS. Poster.

Oriana Zambito*, Leanne Ohlund, Chirine Toufaily, Rodolphe Soret, Nicolas Pilon, Lekha Sleno. Multi-omic analysis of Hirschsprung’s disease in a mouse model. Oral (abstract selected, presentation prize).

Lekha Sleno, Timon Geib*, Ghazaleh Moghaddam*, Makan Golizeh*. Analysis of Acetaminophen Covalent Binding Targets in vivo by LC-MRM. Invited talk.

Lekha Sleno, Timon Geib*, Ghazaleh Moghaddam*, Makan Golizeh*. Analysis of Acetaminophen Covalent Binding Targets in vivo by LC-MRM. Invited talk.

Maggy Lépine*, Oriana Zambito*, Jean-Yves Sahyoun, Marie-Claude Robert, Lekha Sleno. An innovative targeted workflow for measuring quantitative changes in the tear proteome of patients with common and rare eye diseases. Oral (Lake Louise travel award).

Ons Ousji*, Mbarka Bchetnia, Catherine Laprise, Lekha Sleno. Integrating metabolomics, proteomics and transcriptomics data to decipher molecular perturbations in Epidermolysis bullosa simplex, a rare skin disease. Poster.

Lekha Sleno, Ikram Benhadji Serradj*, Ons Ousji*, Said Matar*, Nathan Ghafari*, Leanne Ohlund. Exposomics analysis in urine: spectral libraries to detect metabolites of environmental contaminants. Oral.

Lekha Sleno. Bioanalytical strategies in quantitative targeted proteomics and the study of modifications from reactive metabolites. Invited talk.

Lekha Sleno. Studying the Metabolism of Environmental Contaminants by LC-HRMS/MS. Oral (invited).

Maggy Lépine*, Lekha Sleno. Developing a targeted mass spectrometry workflow for investigating the tear proteome. Poster.

Maggy Lépine*, Lekha Sleno. Étude protéomique des larmes humaines par LC-MS/MS. Oral.

Kahina Chabi*, Timon Geib*, Lekha Sleno. Dépistage des métabolites réactifs par LC-MS/MS en utilisant différents agents de piégeage ainsi que le marquage isotopique. Oral.

Maggy Lépine*, Oriana Zambito*, Lekha Sleno. (2021). Developing a targeted mass spectrometry workflow for investigating the tear proteome from healthy volunteers. Poster.

Ons Ousji*, Lekha Sleno. In vitro metabolism of bisphenol A analogs by LC-HRMS/MS, Poster

Ons Ousji*, Lekha Sleno. Les métabolites réactifs des contaminants environnementaux étudiés par LC-MS/MS. Oral.

Maggy Lépine*, Leanne Ohlund, Lekha Sleno. Analyse protéomique de larmes par chromatographie liquide couplée à la spectrométrie de masse. Oral.

Myriam Mireault*, Vivaldy Prinville*, Leanne Ohlund, Lekha Sleno. Effet de l’acétaminophène sur le profil plasmatique d’acides biliaires chez le rat. Oral.

Timon Geib*, Lekha Sleno. Investigating drug reactive metabolite binding to proteins. Poster.

Ons Ousji*, Lekha Sleno. Les métabolites réactifs des contaminants environnementaux étudiés par LC-MS/MS. Oral.

Maxime Sansoucy*, Franziska Jehle, Matt Harrington, Lekha Sleno. Investigating byssogenesis with proteomic and transcriptomic analysis of byssus, foot and mantle in Mytilus mussels by LC-MS/MS. Oral.

Ons Ousji*, Lekha Sleno. Studying the metabolism of synthetic antioxidants by LC-HRMS/MS. Oral.

Maggy Lépine*, Lekha Sleno. Characterization of the human tear proteome by LC-MS/MS. 36 th Annual Trent Conference on Mass Spectrometry, Montréal. Oral.

Myriam Mireault, Vivaldy Prinville, Leanne Ohlund, Lekha Sleno. Semi-targeted LC-MS/MS analysis of bile acid perturbations by acetaminophen in rat and human. Oral

Kahina Chabi*, Timon Geib*, and Lekha Sleno. Untargeted analysis and relative quantitation of wine thiols using isotope labeling and LC-MS/MS. Oral.

Timon Geib*, Lekha Sleno.  HRMS/MS vs. MRM: screening protein adducts of acetaminophen and clozapine. Oral.

Ons Ousji*, Leanne Ohlund, Lekha Sleno. In vitro metabolism of bisphenol A and five analogs in human and rat liver microsomes by LC-HRMS/MS. Poster.

Maggy Lépine, Sébastien Gagné, Jacques Lesage, Lekha Sleno. Determining isocyanate exposure in human urine by LC-MRM. Poster.

Amal Guesmi*, Leanne Ohlund, Lekha Sleno. Studying the metabolism of sunscreen compounds in vitro by LC-HRMS/MS. Poster.

Maxime Sansoucy*, Felix Friedrich*, Lekha Sleno. Comparison of Reverse Phase and Ion Exchange Fractionation Strategies for 2D-LC-MS/MS Based Liver Proteomics. Poster.

Lekha Sleno. Studying reactive metabolites by mass spectrometry. Oral (invited).

Lekha Sleno, Vivaldy Prinville*, Leanne Ohlund. Quantitative analysis of bile acids to study effect of acetaminophen in rat. Oral (invited).

Maggy Lépine*, Sébastien Gagné, Jacques Lesage, Lekha Sleno. Determining isocyanate exposure in human urine by LC-MRM. Poster.

Ons Ousji*, Leanne Ohlund, Lekha Sleno. In vitro metabolism of bisphenol A and five analogs in human and rat liver microsomes by LC-HRMS/MS. Poster.

Vivaldy Prinville*, Leanne Ohlund, Lekha Sleno. Quantitative LC-MRM Analysis of 47 Bile Acids to Study Effect of APAP in rat plasma. Poster.

Amal Guesmi*, Lekha Sleno. Triclosan metabolism studied by LC-HRMS/MS. Poster.

Maxime Sansoucy*, Réjean Tremblay, Isabelle Marcotte, Lekha Sleno. Proteomic Investigation of Mytilidae Mussels by 2D-LC-HRMS/MS Aimed at Characterizing Byssus-Related Proteins. Poster.

Maxime Sansoucy*, Felix Friedrich*, Lekha Sleno. Comparison of reverse phase and ion exchange fractionation strategies for 2D-LC-HRMS/MS based liver proteomics. Poster.

Ons Ousji*, Leanne Ohlund, Lekha Sleno. Analyse métabolomique de l’épidermolyse bulleuse simplexe. Oral.

Vivaldy Prinville*, Leanne Ohlund, Lekha Sleno. Quantitative LC-MRM Analysis of 47 Bile Acids to Study Effect of APAP in rat plasma. Poster.

Timon Geib*, Lekha Sleno. HRMS/MS vs. MRM: Screening protein adducts of acetaminophen and clozapine. Poster.

Maxime Sansoucy*, Felix Friedrich, Lekha Sleno. Comparison of reverse phase and ion exchange fractionation strategies for 2D-LC-HRMS/MS based liver proteomics. Poster.

Maggy Lépine*, Lekha Sleno, Jacques Lesage, Sébastien Gagné. Determining isocyanate exposure in human urine by LC-MRM. Poster.

Ons Ousji*, Leanne Ohlund, Lekha Sleno. In vitro metabolism of bisphenol A and five analogs by LC-HRMS/MS. Poster.

Timon Geib*, Lekha Sleno. Investigating Clozapine-Related Protein Binding in Vitro by LC-MS/MS. Poster.

Lekha Sleno, Vivaldy Prinville^*, Carmai Seto, Khatereh Motamedchaboki.Untargeted microflow metabolomics to decipher metabolic changes upon acetaminophen treatment in rats. Oral (invited).

Lekha Sleno. Workshop sur la protéomique et la métabolomique par LC-MS/MS. Oral (invited tutorial).

Maxime Sansoucy*, Réjean Tremblay, Isabelle Marcotte, Lekha Sleno. Proteomic Investigation of Mytilidae Mussels by 2D-LC-HRMS/MS Aimed at Characterizing Byssus-Related Proteins. Oral.

Maggy Lépine*, Lekha Sleno, Jacques Lesage, Sébastien Gagné. Determining isocyanate exposure in human urine by LC-MRM. Poster.

Amal Guesmi*, Leanne Ohlund, Lekha Sleno. Étude in vitro de métabolisme des principes actifs d’écrans solaires par LC-HRMS/MS. Oral.

Ons Ousji*, Leanne Ohlund, Lekha Sleno. Étude in vitro de métabolisme de bisphénol A et ses analogues par LC-HRMS/MS. Oral.

Lekha Sleno*, Vivaldy Prinville, Leanne Ohlund. Untargeted and targeted metabolomics to study the effect of acetaminophen in rat. Oral (invited).

Ons Ousji*, Lekha Sleno. Studying the metabolism of BHT by LC-MS/MS

Timon Geib*, Lekha Sleno. Reactive Metabolite formation and protein binding by LC-MS/MS

Vivaldy Prinville*, Leanne Ohlund, Lekha Sleno. Quantitative analysis of bile acids to study effect of acetaminophen in rat

Maxime Sansoucy^*, Tobias Primel, Alexander Baer, Matt Harrington, Lekha Sleno. Post-translational modifications in biological materials with unique properties

Amal Guesmi*, Lekha Sleno. Triclosan metabolism studied by LC-HRMS/MS

Maggy Lépine*, Lekha Sleno, Jacques Lesage, Sébastien Gagné. Determining isocyanate exposure in human urine by LC-MRM

Lekha Sleno. Studying the metabolism of drugs and environmental contaminants by LC-MS/MS. Oral (invited).

Lekha Sleno, Ons Ousji*, Amal Guesmi*, Leanne Ohlund. Studying the metabolism of environmental contaminants by LC-MS/MS. Oral (invited).

Lekha Sleno, Ons Ousji*, Amal Guesmi*, Leanne Ohlund. Studying the metabolism of environmental contaminants by LC-MS/MS. Oral (invited).

Ons Ousji*, Lekha Sleno. (2019) Bref mon projet : Étude du métabolisme de l’Hydroxytoluène butylé (BHT) et ses analogues in vitro par LC-HRMS/MS, 11^th edition Armand-Frappier-INRS congress, Saint Sauveur, QC, Canada

Maggy Lépine*, Lekha Sleno, Jacques Lesage, Sébastien Gagné. Quantification des biomarqueurs d’exposition des isocyanates dans l’urine humaine par LC-MS.

Maggy Lépine*, Leanne Ohlund, Lekha Sleno. Characterization of the human tear proteome by LC-MS/MS

Timon Geib*, Andrew Fairman, Derek J. Wilson, Lekha Sleno. Investigating Acetaminophen Covalent Protein Binding to Glutathione S-Transferases by LC-MS/MS

Maxime Sansoucy*, Lekha Sleno. Reaction between DOPA and cysteine thiol studied by LC-MS/MS

Myriam Mireault*, Vivaldy Prinville*, Leanne Ohlund, Lekha Sleno. Untargeted LC-MS/MS based metabolomics to decipher metabolic changes upon acetaminophen treatment in rats

Maxime Sansoucy*, Lekha Sleno. Reaction of DOPA with cysteine thiol studied by LC-MS/MS

Maggy Lépine*, Leanne Ohlund, Lekha Sleno. Characterization of the human tear proteome by LC-MS/MS

Timon Geib*, Lekha Sleno. Investigating Drug-Related Protein Binding in Vitro by LC-MS/MS

Timon Geib*, André LeBlanc*, Tze Chieh Shiao, René Roy, Elaine Leslie, Constantine Karvellas Lekha Sleno. Absolute Quantitation of in Vivo Acetaminophen-Modified Human Serum Albumin by LC-MS/MS. Poster.

Maxime Sansoucy*, Lekha Sleno. Studying of cross-linking of nucleophilic amino acids on dopa using high-resolution tandem mass spectrometry. Poster.

Maggy Lépine*, Lekha Sleno, Jacques Lesage, Sébastien Gagné. A validated and practical UPLC-MS/MS method for methylenedianiline determination in human urine. Oral.

Timon Geib*, André LeBlanc*, Tze Chieh Shiao, René Roy, Elaine Leslie, Constantine Karvellas Lekha Sleno. Quantitation of Acetaminophen Covalent Protein Binding in Vivo by LC-MS/MS. Oral.

Timon Geib*, Andrew Fairman, Derek J. Wilson, Lekha Sleno Identification of Acetaminophen-Related Covalent Protein Binding by LC-MS/MS. Poster.

Maxime Sansoucy*, Lekha Sleno. Identification of dopa-modified amino acids using high-resolution tandem mass spectrometry. Poster.

Vivaldy Prinville*, Leanne Ohlund, Lekha Sleno, Quantitative method to analyze the effect of acetaminophen on bile acids in rat plasma by LC-MRM. Poster.

Maggy Lépine*, Lekha Sleno, Jacques Lesage, Sébastien Gagné.A validated and practical UHPLC-MS/MS method for the determination of methylenedianiline in human urine. Poster.

Amal Guesmi^*, Meriem Benmaouche, Leanne Ohlund, Lekha Sleno.Étude de métabolisme in vitro des principes actifs d’écrans solaires par LC-HRMS/MS. Poster.

Amal Guesmi*, Meriem Benmaouche, Leanne Ohlund, Lekha Sleno. Metabolism of Sunscreen Compounds in Rat and Human Liver Microsomes by LC-HRMS/MS. Poster.

Maggy Lépine*, Lekha Sleno, Jacques Lesage, Sébastien Gagné. A Validated and Practical UPLC-MS/MS Method for Methylenedianiline Determination in Human Urine. Poster.

Timon Geib*, Andrew Fairman, Derek J. Wilson, Lekha Sleno. Identification of Acetaminophen Adducts to Glutathione S-Transferases in vitro by LC-MS/MS. Poster.

Vivaldy Prinville*, Leanne Ohlund, Lekha Sleno. Quantitative Method to Analyze the Effect of Acetaminophen on Bile Acids in Rat Plasma by LCMRM. Poster.

Maxime Sansoucy*, Lekha Sleno. Studying Crosslinking of Dopa-Containing Peptides by High-Resolution Tandem Mass Spectrometry. Poster.

Amal Guesmi*, Meriem Benmaouche, Leanne Ohlund, Lekha Sleno. Studying the metabolism of sunscreen compounds in vitro by LC-MS/MS. Poster.

Maggy Lépine*, Lekha Sleno, Jacques Lesage, Sébastien Gagné. Determining levels of methylenedianiline and toluenediamine as biomarkers for isocyanate exposure in human urine by UPLC-MS/MS. Poster.

Timon Geib*, Andrew Fairman, Derek J. Wilson, Lekha Sleno. Investigating Acetaminophen Covalent Protein Binding to Glutathione S-transferases by LC-MS/MS. Poster.

Maxime Sansoucy*, Lekha Sleno. Identification of Dopa-Modified Amino Acids Using High-Resolution Tandem Mass Spectrometry. Poster.

Timon Geib*, Lekha Sleno. LC-HRMS/MS vs. LC-MRM: Screening of Covalent Drug-Protein Adducts. Oral.

Lekha Sleno. Targeted quantitation of covalently modified proteins. Oral (invited).

Lekha Sleno, Amal Guesmi*, Leanne Ohlund. Studying the metabolism of sunscreen components by LC-HRMS/MS. Oral (invited).

Maggy Lépine*, Lekha Sleno, Jacques Lesage, Sébastien Gagné. A validated and practical UPLC-MS/MS method for methylenedianiline determination in human urine. Oral.

Vivaldy Prinville*, Leanne Ohlund, Lekha Sleno. Quantitative Method to Analyze the Effect of Acetaminophen on Bile Acids in Rat Plasma by LC-MRM. Oral.

Lekha Sleno, Amal Guesmi*, Leanne Ohlund. Studying the metabolism of sunscreen components by LC-HRMS/MS. Oral (invited).

Ons Ousji*, Leanne Ohlund, Lekha Sleno. In vitro oxidative metabolism and GSH adduct formation of bisphenol A analogs by LC-MS/MS. Poster.

Vivaldy Prinville*, Leanne Ohlund, Lekha Sleno. Quantitative Method to Analyze the Effect of Acetaminophen on Bile Acids in Rat Plasma by LC-MRM. Poster.

Amal Guesmi*, Leanne Ohlund, Lekha Sleno. Studying the metabolism of sunscreen compounds in vitro using LC-MS/MS. Poster.

Timon Geib*, Andrew Fairman, Derek J. Wilson, Lekha Sleno. Investigating Acetaminophen Covalent Protein Binding to Glutathione S-Transferases by LC-MS/MS. Poster.

Maxime Sansoucy* and Lekha Sleno.Comparison of pre-fractionation methods for 2D-LC-MS/MS analysis of liver proteins. Poster.

Lekha Sleno. Targeted quantitation of covalently modified proteins. Oral (invited).

Ons Ousji*, Leanne Ohlund, Lekha Sleno. In vitro metabolism of bisphenol A and five analogs in human liver microsomes by LC-MS/MS. Poster.

Vivaldy Prinville*, Leanne Ohlund, Lekha Sleno. Quantitative Method to Analyze the Effect of Acetaminophen on Bile Acids in Rat Plasma by LC-MRM. Oral.

Maggy Lépine*, Lekha Sleno, Jacques Lesage, Sébastien Gagné. Determining isocyanate exposure in human urine by LC-MRM. Poster.

Timon Geib*, Lekha Sleno. Identification of Acetaminophen-Related Covalent Protein Binding to Glutathione S-Transferase by LC-MS/MS. Poster.

Amal Guesmi*, Leanne Ohlund, Lekha Sleno. Studying the Metabolism of Sunscreen Compounds In Vitro Using LCMS/MS. Poster.

Maxime Sansoucy*, Felix Friedrich, Lekha Sleno. Comparison of Pre-Fractionation Methods for Comprehensive Analysis of Liver Proteins by 2D-LC-MS/MS. Oral.

Timon Geib*, Lekha Sleno. HRMS/MS vs. MRM: Screening protein adducts of acetaminophen and clozapine. Oral (travel award).

Lekha Sleno, Vivaldy Prinville*, Leanne Ohlund. Quantitative LC-MRM analysis of 47 bile acids to study effect of APAP in rat plasma. Poster.

Ghazaleh Moghaddam*, Makan Golizeh*, Lekha Sleno. Proteomic analysis of mouse and rat liver after acetaminophen treatment by 2D-LC-HRMS/MS. Oral.

Maxime Sansoucy*, Réjean Tremblay, Isabelle Marcotte, Lekha Sleno. Multi-dimensional LC-MS/MS of Mytilus edulis mussel proteins related to byssogenesis. Oral.

Lekha Sleno. Workshop sur la protéomique et la métabolomique par LC-MS/MS. Oral (invited).

Maxime Sansoucy*, Réjean Tremblay, Isabelle Marcotte, Lekha Sleno. Comparative proteomics of mussel studying proteins associated to byssus filament formation by 2D-LC-MS/MS. Oral.

Timon Geib*, André LeBlanc*, Tze Chieh Shiao, Ghazaleh Moghaddam*, Amal Guesmi, Cornelia Sommersdorf, Oliver Poetz, René Roy, Lekha Sleno. Absolute quantitation of modified human serum albumin for accurately monitoring acetaminophen-related hepatotoxicity. Oral.

Timon Geib*, André LeBlanc*, Tze Chieh Shiao, Cornelia Sommersdorf, Oliver Poetz, René Roy, Lekha Sleno. Acetaminophen-related hepatotoxicity monitoring in human serum by liquid chromatography-mass spectrometry. Poster.

Ghazaleh Moghaddam*, Makan Golizeh*, Lekha Sleno. Identification of liver protein biomarkers of acetaminophen covalent binding and hepatotoxicity using 2D-LC-HRMS/MS. Poster.

Maxime Sansoucy*, Réjean Tremblay, Isabelle Marcotte, Lekha Sleno. Comparative proteomics of different mussel species to reveal proteins linked to byssogenesis by 2D-LC-MS/MS. Poster.

Timon Geib*, André LeBlanc*, Tze Chieh Shiao, Ghazaleh Moghaddam*, Amal Guesmi, Cornelia Sommersdorf, Oliver Poetz, René Roy, Lekha Sleno. Absolute quantitation of acetaminophen-modified HSA by LC-MRM. Poster.

Maxime Sansoucy*, Réjean Tremblay, Isabelle Marcotte, Lekha Sleno. Comparative Proteomics on Mytilidae Species Revealing Potential Byssus-Related Proteins using 2D-LC-MS/MS. Poster.

Ghazaleh Moghaddam*, Makan Golizeh*, Lekha Sleno. Identification of APAP covalent binding protein targets in rat and mouse liver by 2D-LC-HRMS/MS. Poster.

Timon Geib*, André LeBlanc*, Tze Chieh Shiao, René Roy, Lekha Sleno. Absolute quantitation of acetaminophen-modified HSA by LC-MRM. Poster.

Maxime Sansoucy*, Réjean Tremblay, Isabelle Marcotte, Lekha Sleno. Relative Quantitation of DOPA-Related Collagen Crosslinking using LC-MS. Poster.

Timon Geib*, André LeBlanc*, Tze Chieh Shiao, René Roy, Elaine Leslie, Constantine Karvellas, Lekha Sleno. Absolute quantitation of acetaminophen-modified HSA by LC-MS/MS. Oral.

Maxime Sansoucy*, Leanne Ohlund, Lekha Sleno. Analysis of Dopa-Modified Amino Acids by LC-MS/MS. Poster.

Ghazaleh Moghaddam*, Makan Golizeh*, Lekha Sleno. Protein targets of acetaminophen in rat and mouse liver using 2D-LC-HRMS/MS. Poster.

Ghazaleh Moghaddam*, Lekha Sleno. Method optimization and quantification of acetaminophen dose-dependent metabolites using HR-MS and MRM. Poster.

Biao Ji*, Joannie Emond*, Leanne Ohlund*, Jennifer Chiang, Guri Giaever, Corey Nislow, Lekha Sleno. Global metabolic profiling of effect of auxotrophy in yeast via UHPLC-HRMS/MS. Poster.

Maxime Sansoucy*, Makan Golizeh*, Pat Forgione, Lekha Sleno. A Quantitative Approach using LC-MS in Hepatitis C Virus NS 2/3 Protease Autolysis Inhibition. Oral.

Ghazaleh Moghaddam*, Makan Golizeh*, Lucie Huart*, Lekha Sleno. An in vivo study to identify APAP covalent binding protein targets in rat liver by 2D-LC-HRMS/MS. Poster.

Maxime Sansoucy*, Makan Golizeh*, Pat Forgione, Lekha Sleno. A Quantitative Approach using LC-MS in Hepatitis C Virus NS 2/3 Protease Autolysis Inhibition. Poster.

Ghazaleh Moghaddam*, Lekha Sleno. Global metabolomics approach for identifying acetaminophen dose-dependent metabolites using HRMS and MRM. Poster.

Lekha Sleno, Timon Geib*, André LeBlanc*, Makan Golizeh*, Ghazaleh Moghaddam*. Quantitation of acetaminophen protein binding in human plasma. Oral.

Lekha Sleno, André LeBlanc*, Makan Golizeh*. Monitoring reactive metabolite-induced covalent modification of proteins by LC-MS/MS. Oral (invited).

André LeBlanc*, Marine Bouaziz*, Tze Chieh Shiao, René Roy, Lekha Sleno. Development of a sample enrichment protocol using click chemistry for identification of protein targets of reactive metabolites in liver microsomes. Poster.

Biao Ji*, Leanne Ohlund*, Jennifer Chiang, Guri Giaever, Corey Nislow, Lekha Sleno. Differentiating yeast strains by untargeted metabolomics using UHPLC-HRMS/MS. Poster.

Maxime Sansoucy*, Cynthia Caron, Makan Golizeh*, Réjean Tremblay, Isabelle Marcotte, Lekha Sleno. Protein characterization involved in mussel byssal threads biogenesis by 2D-LC-MS/MS. Poster.

Makan Golizeh*, André LeBlanc*, Lekha Sleno. Identification of liver proteins targeted by reactive metabolites using LC-MS/MS. Poster.

Lekha Sleno, Ghazaleh Moghaddam*, Leanne Ohlund*. Profiling acetaminophen dose-dependent metabolites in rat plasma by untargeted UHPLC-HRMS/MS. Poster.

Maxime Sansoucy*, Makan Golizeh*, Réjean Tremblay, Isabelle Marcotte, Lekha Sleno. Method development for characterizing mussel foot proteins involved in byssal formation. Oral.

Timon Geib*, Dietrich Volmer, Lekha Sleno. A comparison of low and high resolution mass spectrometry for Vitamin D quantitation. Oral.

Lekha Sleno, André LeBlanc*, Makan Golizeh*. Reactive drug metabolites and covalent binding. (Toxicoproteomics special interest group). Oral (invited).

Makan Golizeh*, Marine Bouaziz*, André LeBlanc*, Lekha Sleno. Identifying protein targets of reactive metabolite covalent binding by LC-MS/MS. Poster.

Makan Golizeh*, Lekha Sleno. Label-Free LC-MS/MS Analysis of Reactive Metabolite Protein Targets. Oral (invited, best PhD thesis in mass spectrometry in Quebec).

Makan Golizeh*, Timon Geib*, Lekha Sleno. Identification of HNE Protein Targets in Rat, Mouse and Human Liver Microsomes by 2D-LC-MS/MS. Oral.

Biao Ji*, Joannie Emond*, Leanne Ohlund*, Jennifer Chiang, Guri Giaever, Corey Nislow, Lekha Sleno. Differentiating Yeast Strains by Untargeted Metabolomics using UHPLC-HRMS/MS. Poster.

Ghazaleh Moghaddam*, Lekha Sleno. Global acetaminophen dose-dependent metabolite profiling by HPLC-HRMS/MS. Poster.

Maxime Sansoucy*, Makan Golizeh*, Réjean Tremblay, Isabelle Marcotte, Lekha Sleno. Method development for characterizing mussel proteins implicated in byssal threads production using a 3D-LC-MS/MS approach. Oral.

Golizeh, M*, Abusarah J, Mohamed Benderdour, Lekha Sleno. Characterization of HNE modification of matrix metalloproteinase 13 in osteoarthritis patients using HRMS/MS. Poster.

André LeBlanc*, Tze Chieh Shiao, René Roy, Lekha Sleno. LC-MS/MS-based method for the absolute quantitation of NAPQI-modified serum albumin from in vivo rat plasma samples: monitoring actaminophen toxicity. Poster.

Lekha Sleno, Michel Wagner*, Leanne Ohlund*, Maxime Sansoucy*, Yasmine Boukhedimi*. Semi-targeted metabolomics by differential isotope-labeling and HR-MS. Oral (invited).

Michel Wagner*, Leanne Ohlund*, Tze Chieh Shiao, Amélie Vézina, Borhane Annabi, René Roy, Lekha Sleno. Analyse métabolomicque différentielle par étiquettage isotopique et LC-HR-MS : application à l’étude du stress oxydatif de cellules HL60. Oral (invited).

André LeBlanc*, Tze Chieh Shiao, René Roy, Lekha Sleno. Identifying reactive metabolite protein targets in liver microsomes using click chemistry and affinity purification. Poster.

Lekha Sleno, André LeBlanc*, Tze Chieh Shiao, René Roy. Absolute quantitation of NAPQI-RSA by LC-MS/MS: monitoring acetaminophen toxicity. Oral.

Atefeh Rafiei*, Lekha Sleno. A systematic approach to untargeted metabolomics data analysis: comparison of peak picking workflows. Poster.

Leanne Ohlund*, André LeBlanc*, Lekha Sleno. Studying drug metabolism by isotope labeling and high resolution tandem mass spectrometry. Poster.

Michel Wagner*, Leanne Ohlund*, Tze Chieh Shiao, Amélie Vézina, Borhane Annabi, René Roy, Lekha Sleno. Quantitative metabolomics using isotope-labeling, differential analysis and RP-LC-HRMS: Investigation of metabolic perturbations in a cellular model of cancer. Poster.

Lekha Sleno, André LeBlanc*. Absolute quantitation of NAPQI-RSA by LC-MS/MS: monitoring acetaminophen toxicity. Oral (invited).

André LeBlanc*, Lekha Sleno. Novel mass spectrometry-based methodologies to detect, characterize and quantify reactive drug metabolites and their protein adducts. Oral (invited, best PhD thesis in mass spectrometry in Quebec).

André LeBlanc*, Lekha Sleno. Identifying reactive metabolite protein targets using click chemistry. Oral (travel award).

Lekha Sleno, André LeBlanc*, Makan Golizeh*. Qualitative and quantitative analysis of NAPQI protein adducts by LC-MS/MS. Oral.

Lekha Sleno. Bioanalytical mass spectrometry: Applications in semi-targeted metabolomics and protein modifications. Oral (invited).

Lekha Sleno, Julie-Anne Jauffrit*, Fong Lam Chu*, Guri Giaever, Corey Nislow. Targeted and untargeted metabolomics for assessing perturbations of tryptophan metabolism in yeast by LC-MS/MS. Oral (invited).

Lekha Sleno. Semi-targeted metabolomics using differential isotope-labeling strategies. Oral (invited).

Lekha Sleno, Leanne Ohlund*, Audrey Ste-Rose*, Guri Giaever, Corey Nislow. Profiling auxotrophic yeast strains using an untargeted metabolomics approach by LC coupled to HRMS. Oral (invited).

Makan Golizeh*, Avid Hassanpour, Pat Forgione, Lekha Sleno. A novel inhibition assay of HCV NS2/3 protease auto-cleavage by high resolution tandem mass spectrometry. Oral.

André LeBlanc*, Tze Chieh Shiao, René Roy, Lekha Sleno. Development of an in vivo quantitative assay for covalent modified serum albumin: monitoring acetaminophen toxicity. Oral.

André LeBlanc*, Souade Ben Haddou*, Tze Chieh Shiao, René Roy, Lekha Sleno. Development of an in vivo quantitative assay for covalently modified serum albumin: monitoring acetaminophen toxicity. Poster.

Lekha Sleno, Audrey Ste-Rose*, Guri Giaever, Nislow, C. Untargeted metabolomics for profiling auxotrophic yeast strains by LC-QqTOF. Poster.

Michel Wagner*, Yasmine Boukhedimi*, Leanne Ohlund*, Tze Chieh Shiao, Amélie Vézina, Borhane Annabi, Alex Parker, Sarah Jenna, René Roy, Lekha Sleno. Differential analysis for quantitative metabolomics using isotope-labeling and LC-HRMS: data processing strategies. Poster.

Makan Golizeh*, Mohamed Benderdour, Lekha Sleno. New evidence for covalent binding of 4-hydroxynonenal to metalloproteinase 13 using HRMS/MS. Poster.

Lekha Sleno, Audrey Ste-Rose*, Guri Giaever, Corey Nislow. Profiling multiple auxotrophic yeast strains by untargeted metabolomics workflow by high resolution LC-MS/MS. Poster.

Christina Schneider*, Makan Golizeh*, Leanne Ohlund*, Lekha Sleno. Assessing proteome coverage with ion exchange fractionation combined with reverse phase LC-MS/MS for analyzing rat liver proteins. Poster.

Michel Wagner*, Leanne Ohlund*, Tze Chieh Shiao, Amélie Vézina, Borhane Annabi, René Roy, Lekha Sleno. Quantitative metabolomics of amine-containing metabolites using isotope-labelling and differential analysis. Poster.

André LeBlanc*, Souade Ben Haddou*, Tze Chieh Shiao, René Roy, Lekha Sleno. Development of an in vivo quantitative assay for covalently modified serum albumin: monitoring acetaminophen toxicity. Poster.

Atefeh Rafiei*, Lekha Sleno. Precise feature detection: a comparison of peak generating workflows for untargeted metabolomics data analysis. Poster.

Makan Golizeh*, Mohamed Benderdour, Lekha Sleno. New evidence for covalent binding of 4-hydroxynonenal to matrix metalloproteinase 13 using high-resolution tandem mass spectrometry. Poster.

Lekha Sleno, Makan Golizeh*, André LeBlanc. (Studying unconventional protein modifications by high resolution mass spectrometry. Oral (invited).

Lekha Sleno, André LeBlanc*, Souade Ben Haddou*, Tze Chieh Shiao, René Roy. Development of a novel quantitative LC-MS/MS based assay for albumin-acetaminophen adducts. Poster.

Lekha Sleno, Makan Golizeh*, André LeBlanc*. Monitoring reactive metabolite-induced covalent modification of proteins. Oral.

André LeBlanc*, Lekha Sleno. High resolution mass spectrometry and post-acquisition data mining for thorough metabolite screening. Poster.

Lekha Sleno, Fong Lam Chu*, Corey Nislow, Guri Giaever. Profiling metabolites involved in tryptophan biosynthesis and degradation in yeast by quadrupole linear ion trap mass spectrometry. Poster.

Leanne Ohlund*, Véronique Plante*, Amélie Vézina, Tze Chieh Shiao, René Roy, Borhane Annabi, Lekha Sleno. Relative quantitation of amine-containing metabolites in human cells using isotope-labeled derivatization and high resolution quadrupole time of flight mass spectrometry. Poster.

André LeBlanc*, Alexandre Arnold, Bertrand Genard, Jean-Bruno Nadalini, Marc-Olivier Séguin Heine, Isabelle Marcotte, Réjean Tremblay, Lekha Sleno. Quantitation of protein isotopic labeling by precursor ion scan LC-MS/MS. Poster.

Fong Lam Chu*, Karim Hamiche, Sarah Jenna, Lekha Sleno. Lipid profiling in C. elegans embryonic elongation mutants using high resolution-high speed quadrupole time of flight mass spectrometry. Poster.

Yasmine Boukhedimi*, Sarah Jenna, Alex Parker, Lekha Sleno. Targeted metabolomic profiling of a novel C. elegans ALS model using stable isotope labeling and high resolution mass spectrometry. Poster.

Lekha Sleno, Yasmine Boukhedimi*, Fong Lam Chu*, Leanne Ohlund*, Véronique Plante*. Novel methods for (semi)-targeted metabolomics applications by LC-MS/MS. Oral (invited).

Lekha Sleno, Julie-Anne Jauffrit*, Fong Lam Chu*, Corey Nislow, Guri Giaever. Targeted vs untargeted metabolomics for assessing perturbations in yeast tryptophan pathway by LC-MS/MS. Poster.

Lekha Sleno, Julie-Anne Jauffrit*, Fong Lam Chu*, Guri Giaever, Corey Nislow. Targeted and untargeted metabolomics for assessing perturbations of tryptophan metabolism in yeast. Oral (invited).

André LeBlanc*, Tze Chieh Shiao, Souade Ben Haddou*, René Roy, Lekha Sleno. MS/MS fragmentation of cysteine-modified peptides formed via click chemistry. Poster.

Lekha Sleno. Bioanalytical LC-MS applied to reactive drug metabolites and metabolomics. Oral (invited).

Lekha Sleno, Guo X, Souade Ben Haddou*, Tate S, Brigitte Simons. Non-assumptive identification of protein modifications using high resolution-high speed quadrupole TOF-MS/MS analysis. Poster.

André LeBlanc*, Tze Chieh Shiao, René Roy, Lekha Sleno. Optimization of purification protocol for LC-MS/MS analysis of click chemistry-modified peptides in complex protein samples. Poster.

Leanne Ohlund*, Véronique Plante*, Hesna Belainine*, Tze Chieh Shiao, Sébastien Proulx-Bonneau, Borhane Annabi, René Roy, Lekha Sleno. Isotope-labeled differential profiling of amine-containing metabolites in mesenchymal stem cells under hypoxic conditions. Poster.

Souade Ben Haddou*, André LeBlanc*, Tze Chieh Shiao, René Roy, Lekha Sleno. Studying peptide fragmentation differences based on cysteine modifications on a quadrupole-linear ion trap instrument. Poster.

Yasmine Boukhedimi*, Sarah Jenna, Eva Duchoslav, Suma Ramagiri, Lekha Sleno. Novel data acquisition and processing strategies for targeted metabolome profiling using differential isotope labeling and high resolution accurate mass spectrometry. Poster.

Fong Lam Chu*, Sarah Jenna, Julien Schelpe*, Lekha Sleno. Untargeted metabolomics approach for studying C. elegans embryonic elongation using a combination of aqueous normal phase and reverse phase LC-ESI-TOF-MS. Poster.

André LeBlanc*, Lekha Sleno. Thorough metabolite screening using high resolution mass spectrometry and post-acquisition data mining: redefining the metabolism of atrazine. Oral.

Lekha Sleno, X Guo, Souade Ben Haddou*, Stephen A Tate, Brigitte Simons. Non-assumptive identification of protein modifications using high resolution-high speed quadrupole TOF-MS/MS analysis. Oral (invited).

André LeBlanc*, Lekha Sleno. High-resolution mass spectrometry and post-acquisition data mining for thorough screening of reactive metabolites. Oral.

Lekha Sleno. Bioanalytical mass spectrometry research: Applications in drug metabolism and metabolomics. Oral (invited).

Fong Lam Chu*, Laura Pirastru, Radovan Popovic, Lekha Sleno. Targeted metabolomic approach for analyzing carotenoids in algae samples using LC-UV coupled with ESI-MS. Poster.

André LeBlanc*, Lekha Sleno. Atrazine metabolism: Characterization of novel metabolites and glutathione adducts detected by LC-TOF-MS. Poster.

Lekha Sleno, Maude St-Onge*, André LeBlanc*. Assessing covalent binding of reactive drug metabolites by complete digestion followed by LC-MS/MS analysis. Poster.

André LeBlanc*, Tze Chieh Shiao, René Roy, Lekha Sleno. Improved detection of reactive drug metabolites with bromine-containing glutathione analog using mass defect and isotope pattern matching. Poster.

Lekha Sleno, André LeBlanc*, William Maupillier*, Boris Guichard*. Coupling LC-fluorescence with MS/MS for identifying modified amino acids. Poster.

Lekha Sleno, André LeBlanc*, Tze Chieh Shiao, René Roy. Improved detection of reactive drug metabolites with bromine-containing glutathione analog using mass defect and isotope pattern matching. Oral (invited).